The actor has had a long hiatus from acting after her career was derailed by substance addiction and time spent in jail.
During an interview on Lights Out with David Spade earlier this week, Lohan said: “I should probably get back to doing movies at some point. I think I was hanging on to [Mean Girls] for a really long time.
“I wanted to come back with a Mean Girls 2. To work with Tina [Fey], and the whole crew again, and [director] Mark Waters. That was really what I wanted. I was excited to do that.
“But that’s all in their hands, really. So that would definitely be an exciting thing.”
A low-budget sequel to Mean Girls came out in 2011, but the only original cast member to return was Tim Meadows as Principal Ron Duvall. It was a critical flop.
Although there are no official plans for a follow-up to the 2004 comedy with the original cast, Lohan can next be seen in the Netflix thriller series Cursed, alongside Mickey Rourke.