Victory will earn them a place in the last 16, as Ajax and Valencia, their Group H rivals, face off in the other game in group H.
Everton gave Chelsea a reality check on Saturday, outworking them in a 3-1 win.
But after a mixed bag in Europe this season, Lampard will be content at a chance to seal qualification to the knock-out phase.
Here are the predicted line-ups for the game.
When and where is the match?
The match is on Tuesday at 20:00 GMT at Stamford Bridge, London.
The Blues were poor at Goodison Park at the weekend, weak defending set-pieces and crosses and could not match the desire of Everton, but Lille pose a different threat with the game’s tempo likely to suit the slicker passing of the hosts. We expect the Blues to bounce back here and clinch a place in the last 16. We’ll go with 2-0.
How can I watch the match?
You can watch the match on BT Sport 2 – coverage starts at 19:00 GMT.
Can I watch a live stream online?
Yes, you can catch the game on the BT Sport app on mobile devices here.
Tammy Abraham picked up another knock to his bruised hip, which has caused him aggravation in recent weeks. Antonio Rudiger is back in the squad, while Fikayo Tomori is out with a hip strain. Olivier Giroud remains out.
Chelsea: Kepa; James, Zouma, Christensen, Azpilicueta; Kante, Jorginho, Kovacic; Willian, Abraham, Pulisic
Lille: Maignan; Celik, Fonte, Gabriel, Bradaric; Soumare, Andre; Sanches, Ikone, Bamba; Osimhen