The Blues are currently on the outside looking in, but know Ajax and Valencia, who play each other in the other Group H match in game week six, cannot both surpass their 11-point total, should they beat the French side.
Frank Lampard will be expecting a reaction after their poor display to lose to Everton on Saturday.
Should Ajax falter, a Chelsea win will take top spot, due to their superior head-to-head record against the Dutch side.
Here’s how you can watch the game tonight.
When and where is the match?
The match is on Tuesday at 20:00 GMT at Stamford Bridge, London.
The Blues were poor at Goodison Park at the weekend, weak defending set-pieces and crosses and could not match the desire of Everton, but Lille pose a different threat with the game’s tempo likely to suit the slicker passing of the hosts. We expect the Blues to bounce back here and clinch a place in the last 16. We’ll go with 2-0.
How can I watch the match?
You can watch the match on BT Sport 2 – coverage starts at 19:00 GMT.
Can I watch a live stream online?
Yes, you can catch the game on the BT Sport app on mobile devices here.
Tammy Abraham picked up another knock to his bruised hip, which has caused him aggravation in recent weeks. Antonio Rudiger is back in the squad, while Fikayo Tomori is out with a hip strain. Olivier Giroud remains out.
Chelsea: Kepa; James, Zouma, Christensen, Azpilicueta; Kante, Jorginho, Kovacic; Willian, Abraham, Pulisic
Lille: Maignan; Celik, Fonte, Gabriel, Bradaric; Soumare, Andre; Sanches, Ikone, Bamba; Osimhen