Alzheimer's Researchers Study a Rare Brain

Alzheimer’s Researchers Study a Rare Brain

Alzheimer’s Researchers Study a Rare Brain

Alzheimer’s Researchers Study a Rare Brain

Each brain donation begins not in a hospital mortuary but in a large and well-equipped funeral home. The arrangement allows the researchers to remove the brain and walk it quickly to their dissection lab a block away, after which the family can proceed with a funeral or cremation.

Aliria’s autopsy started at 11:30 a.m., three hours after her death. Dr. Villegas’s senior team members, Dr. Aguillon and Johana Gómez, a biologist, suited up in plastic overalls, masks and face shields, precautions made necessary by the pandemic, while a medical student, Carlos Rueda, stood by taking notes.

The team removed the brain with relative ease, although the process is always intricate, with connective tissue that must be carefully severed. Dr. Villegas then extracted from deeper in the skull the pituitary gland and olfactory membrane, structures of interest to Alzheimer’s researchers. The group took samples of skin, tumor and vital organs, before leaving the remains of their famous patient, one on whom so many research hopes have been pinned, to be cremated.

Within minutes the group converged again down the street at the brain bank’s dissection lab, a room no bigger than a walk-in closet. It was nearly 1 p.m., and Dr. Aguillon placed Aliria’s brain on a scale. It weighed 894 grams, just under two pounds — considerably less than a healthy brain. Mr. Rueda began photographing it on a rotating platform used to create a three-dimensional image, while Dr. Villegas narrated and Dr. Aguillon typed.

Dr. Villegas noted that the brain had atrophied in a way that appeared typical for an Alzheimer’s patient, and that he saw little evidence of cancer, although it was present in many other organs. The brain’s low weight struck Dr. Villegas as curious given that Aliria’s symptoms were not yet so advanced; in the months before her death, she still recognized her family and friends, still cooked her own meals and bathed herself, and had no trouble recalling words like “neuroscience” and “coronavirus.”


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